Videos uploaded by user “NEJMvideo”
NEJM Procedure: Deployment of an Endovascular Graft in an Abdominal Aortic Aneurysm
Aneurysm repair is a mechanical solution to the problem of progressive expansion of abdominal aortic aneurysm and the risk of rupture. Although open surgical repair, which has been the established approach, is very effective, it carries substantial risks from the extensive surgical procedure. Endovascular repair was developed to reduce the risks associated with open surgery and to provide a treatment option for patients who are not deemed to be surgical candidates.
Views: 120448 NEJMvideo
Cycling for Freezing Gait in Parkinson's Disease
A 58-year-old man with a 10-year history of idiopathic Parkinson's disease presented with an incapacitating freezing of gait. However, the patient's ability to ride a bicycle was remarkably preserved. (In Video 2, the patient is not wearing a safety helmet because in the Netherlands, wearing a safety helmet is neither required by law nor customary.) http://bit.ly/c4BQ2f
Views: 279968 NEJMvideo
Measurement of the Hepatic Venous Pressure Gradient (HVPG)
Measurement of the Hepatic Venous Pressure Gradient (HVPG)
Views: 39845 NEJMvideo
NEJM Procedure: Endoscopic Management of Acute Bleeding from a Peptic Ulcer
Acute upper gastrointestinal hemorrhage, which is defined as bleeding proximal to the ligament of Treitz, is a prevalent and clinically significant condition with important implications for health care costs worldwide. Negative outcomes include rebleeding and death, and many of the deaths are associated with decompensation of coexisting medical conditions precipitated by the acute bleeding event. This video focuses specifically on endoscopic management of acute bleeding from a peptic ulcer. See the August 28, 2008, Current Concepts review article: "Management of Acute Bleeding from a Peptic Ulcer" http://www.nejm.org/doi/full/10.1056/NEJMra0706113
Views: 76880 NEJMvideo
NEJM Procedure: Primary PCI for Myocardial Infarction with ST-Segmented Elevation
Reperfusion therapy (mechanical or pharmacologic) is indicated for patients with chest pain consistent with a myocardial infarction with a duration of 12 hours or less in association with ST-segment elevation greater than 0.1 mV in two or more contiguous electrocardiographic leads or a new (or presumed new) left bundle-branch block. Primary PCI is preferred if a skilled interventional cardiologist and catheterization laboratory with surgical backup are available and if the procedure can be performed within 90 minutes after initial medical contact with the patient.
Views: 37389 NEJMvideo
Nut Consumption and Mortality
The NEJM Original Article, "Association of Nut Consumption with Total and Cause-Specific Mortality," is summarized in an NEJM Quick Take. See the study: http://www.nejm.org/doi/full/10.1056/NEJMoa1307352
Views: 20779 NEJMvideo
The Epidemiology of In-Flight Medical Emergencies
New research on medical emergencies aboard commercial airliners is summarized in this NEJM Quick Take, a short video animation. See the NEJM article, "Outcomes of Medical Emergencies on Commercial Airline Flights": http://www.nejm.org/doi/full/10.1056/NEJMoa1212052
Views: 29473 NEJMvideo
Four Examples of Ataxia
Video 1—Friedreich's Ataxia: A patient with Friedreich's ataxia, a gait disorder due to both cerebellar and proprioceptive ataxia, has imbalance, staggers, and has difficulties in making a half-turn. Because of difficulties with tandem walking, the patient requires the intermittent support of a wall. The patient has dysmetria during nose--finger and finger chase tests, and instability in a standing position with the feet together because of cerebellar ataxia. There is an obvious loss of balance when the patient's eyes are closed because of the proprioceptive component of the ataxia. Saccadic ocular pursuit and square-wave jerks due to fixation instability are shown, as well as diffuse abolition of the reflexes and right extensor plantar reflex. Video 2—Ataxia with Oculomotor Apraxia Type 1: Choreic movement of the hands and trunk with cervical dystonia in a patient with ataxia with oculomotor apraxia type 1. Video 3—Ataxia Telangiectasia: Right horizontal gaze-evoked nystagmus and nasal as well as temporal telangiectasias in a patient with ataxia telangiectasia. Video 4—Oculomotor Apraxia Type 1: Oculocephalic dissociation in a patient with ataxia with oculomotor apraxia type 1. During the rotation of the head, a dissociation is expressed as a delay between the movement of the eyes following that of the head.
Views: 340710 NEJMvideo
Two Videos Showing Fluoroscopy and Animation of the TAVI Procedure
Fluoroscopy with Videography Showing Deployment of the Valve: The valve is deployed during rapid right ventricular pacing. The crimped valve and support frame are expanded with underlying balloon inflation. Also seen are the transesophageal echocardiography probe and the temporary right ventricular pacing lead. Animation of the Complete Transfemoral Transcatheter Aortic-Valve Implantation (TAVI) Procedure: The procedure for transfemoral TAVI involves insertion of the sheath through the femoral artery, retrograde balloon aortic valvuloplasty, advancement of the TAVI system across the aortic valve, and subsequent deployment of the valve and support frame.
Views: 157697 NEJMvideo
The SPRINT Trial
Learn results from the SPRINT trial on intensive blood pressure management in less than 2 minutes with new NEJM Quick Take video summary. #AHA15 http://nej.md/1lfHkLD See the NEJM article, "A Randomized Trial of Intensive versus Standard-Blood Pressure Control":http://www.nejm.org/doi/full/10.1056/NEJMoa1511939
Views: 10687 NEJMvideo
Risk of Cancer in a CT-Discovered Nodule
New research on the malignancy risk of pulmonary nodules first identified on low-dose CT screening is summarized in a short animation, available at NEJM.org. See the NEJM article: Probability of Cancer in Pulmonary Nodules Detected on First Screening CT http://www.nejm.org/doi/full/10.1056/NEJMoa1214726
Views: 9115 NEJMvideo
PARADIGM-HF: A Concise Summary with Journal Club Questions
A three-minute summary of the PARADIGM-HF trial includes five Journal Club questions. See the NEJM article, "Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure": http://www.nejm.org/doi/full/10.1056/NEJMoa1409077 See the related editorial, "Neprilysin Inhibition — A Novel Therapy for Heart Failure": http://www.nejm.org/doi/full/10.1056/NEJMe1409898 See the related Perspective article: "Paradigm Shifts in Heart-Failure Therapy — A Timeline": http://www.nejm.org/doi/full/10.1056/NEJMp1410241
Views: 6810 NEJMvideo
Intravenous Fluids and Patient Outcomes
Intravenous administration of isotonic crystalloid fluids is one of the most common medical therapies, but whether the composition of the fluid has an effect on outcomes has not been known. New research findings are summarized in this short video. Full SALT-ED trial results: http://nej.md/2F6uHQF Watch more Quick Take videos: http://nej.md/quick-take
Views: 9456 NEJMvideo
Ischemic Optic Neuropathies
A new review article covers the diagnosis, pathophysiological features, and prognosis of ischemic optic neuropathy, a relatively common cause of visual loss in older patients, including visual loss after cardiac surgery. It must be distinguished from inflammatory optic neuritis. Read the full article: http://www.nejm.org/doi/full/10.1056/NEJMra1413352
Views: 22468 NEJMvideo
NEJM Procedure: Thrombus Aspiration
In an occluded infarct-related artery, reperfusion can be achieved by the standard means of primary percutaneous coronary intervention or by the new method of thrombus aspiration, followed by stenting, as depicted in this video.
Views: 23838 NEJMvideo
Maneuvers to Diagnosis and Treat Benign Paroxysmal Positional Vertigo
Videos show the patterns of nystagmus that are diagnostic of the two most common types of BPPV and demonstrate the movements of the body that should be performed to treat each type. See the NEJM Clinical Practice article, "Benign Paroxysmal Positional Vertigo": http://www.nejm.org/doi/full/10.1056/NEJMcp1309481
Views: 433672 NEJMvideo
Leadless Cardiac Pacemaker.
The video shows the technique for implantation of the Nanostim leadless cardiac pacemaker. See the NEJM article, "Percutaneous Implantation of an Entirely Intracardiac Leadless Pacemaker": http://www.nejm.org/doi/full/10.1056/NEJMoa1507192
Views: 16451 NEJMvideo
A Novel Hemophilia A Therapy
Severe hemophilia A is often treated with infusions of factor VIII. But the infusions are burdensome, and antibodies develop in about 30% of patients. Would emicizumab, which mimics the function of factor VIII, reduce these problems? New research findings are summarized in a new NEJM Quick Take video. Learn more at http://nej.md/1WoeHdF
Views: 6857 NEJMvideo
Parasite-Derived Cancer
Can malignant transformation of parasite cells cause neoplasms in an immunosuppressed host? New research findings are summarized in this new Quick Take video. See the NEJM article, "Malignant Transformation of Hymenolepis nana in a Human Host": http://www.nejm.org/doi/full/10.1056/NEJMoa1505892
Views: 33566 NEJMvideo
The Risk of Stroke after Transient Ischemic Attack
The elevated risk of stroke or acute coronary syndrome after a transient ischemic attack can be estimated with a scoring system in which a high score indicates the need for urgent evaluation. Has this approach led to a reduction in risk? New research findings are summarized in this NEJM Quick Take video. Learn more at http://nej.md/1VgADsh
Views: 8763 NEJMvideo
Quick Take: Cardiovascular Safety of Celecoxib
NSAIDS such as ibuprofen and naproxen can provide pain relief but may increase the risk of GI bleeding. Previous studies showed that high doses of celecoxib increased cardiovascular harm, but the safety of modest doses was unclear. New research findings are summarized in this short video. Access the full Original Article: http://nej.md/2fynoCi
Views: 9645 NEJMvideo
Treating Latent Tuberculosis
Isoniazid is the recommended treatment for latent tuberculosis infection, but its benefit is substantially reduced because of hepatotoxicity and poor rates of regimen completion. New research findings are summarized in this short video. Full study: https://nej.md/2OycQ6Z Watch more Quick Take videos: http://nej.md/quick-take
Views: 4621 NEJMvideo
Mass Intoxication with a Synthetic Cannabinoid
In July 2016, emergency services in Brooklyn responded to a scene of mass intoxication of 33 persons who had been exposed to an “herbal incense” product. How was the cause of their zombielike behavior identified? New research findings are summarized in this short video. Full study: http://nej.md/2gxxh1J
Views: 8015 NEJMvideo
The BRIDGE Trial
Patients with atrial fibrillation are at increased risk of stroke. Warfarin anticoagulation is often used to reduce risk, but it is usually stopped perioperatively. Temporary “bridging” with heparin is common, but is it necessary? New research findings are summarized in a short video. See the NEJM article: "Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation": http://www.nejm.org/doi/full/10.1056/NEJMoa1501035
Views: 3989 NEJMvideo
Reducing the Risk of Preeclampsia in Pregnant Women
Preterm preeclampsia is an important cause of maternal and perinatal death and complications. Low-dose aspirin has been recommended for pregnant women considered to be at high risk. New research findings are summarized in this short video. Full study results: http://nej.md/2todAEI Watch more Quick Take videos: http://nej.md/quick-take
Views: 13387 NEJMvideo
Benefits and Risks of Salt Consumption
What do we know about salt and cardiovascular disease? Current guidelines and statistics are summarized in a short animation.
Views: 11379 NEJMvideo
Reducing Exacerbations in COPD
Studies have shown that triple inhaled therapy has benefits in patients at risk for frequent or severe COPD exacerbations, but the therapy has required the use of multiple inhalers several times a day. Full study: https://nej.md/2I6BfjW Watch more Quick Take videos: http://nej.md/quick-take
Views: 3567 NEJMvideo
Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease
Patients with sickle cell disease may experience pain crises related to P-selectin, which contributes to vaso-occlusion. Would an antibody that blocks binding to P-selectin reduce the frequency of pain crises? New research findings are summarized in this short video. Full study: http://www.nejm.org/doi/full/10.1056/NEJMoa1611770
Views: 4644 NEJMvideo
Treating Neonatal Abstinence Syndrome
Babies who were exposed to opioids in utero are at risk for neonatal abstinence syndrome. New research findings are summarized in this short video. Full study: http://nej.md/2p8NrUn View more Quick Take videos: http://nej.md/quick-take
Views: 6823 NEJMvideo
Sesquizygotic Twinning
Sesquizygotic twins share between 50% and 100% of their genomic sequences and are therefore on a continuum between monozygosity and dizygosity. Read the full Brief Report: "Molecular Support for Heterogonesis Resulting in Sesquizygotic Twinning." https://nej.md/2BS0Zfg
Views: 3213 NEJMvideo
MR CLEAN — A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke
A new Quick Take video summary gives an overview of the recently published results of the MR CLEAN trial, which found that for patients with acute ischemic stroke caused by a proximal occlusion of the anterior circulation, intra-arterial therapy administered within six hours of symptom onset can improve functional outcomes. Read the full NEJM Original Article: http://www.nejm.org/doi/full/10.1056/NEJMoa1411587
Views: 13713 NEJMvideo
Radium-223 and Metastatic Prostate Cancer
In a study involving men with castration-resistant prostate cancer and bone metastases, the alpha emitter radium-223 significantly prolonged survival, as compared with placebo, and was associated with fewer adverse events. See the NEJM article: http://www.nejm.org/doi/full/10.1056/NEJMoa1213755
Views: 10992 NEJMvideo
Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents
Effective antivirals are needed for the treatment and prevention of influenza virus infections but circulating influenza viruses are increasingly resistant to the antiviral agents currently in use. Full study: https://nej.md/2Q4l6wt Browse the Quick Take video archive: http://nej.md/quick-take
Views: 3988 NEJMvideo
The ANNEXA-A and ANNEXA-R Trials
Factor Xa inhibitors, used to prevent and treat thromboembolism, can cause bleeding. Andexanet was designed to reverse the anticoagulant effects of these inhibitors. Is andexanet efficacious? New research findings are summarized in this short video. See the NEJM article, "Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity (ANNEXA)": http://www.nejm.org/doi/full/10.1056/NEJMoa1510991
Views: 4153 NEJMvideo
Treatment for Postinfectious Hydrocephalus in Infants
In sub-Saharan Africa, a large number of infants are affected by hydrocephalus that develops after neonatal ventriculitis and is often associated with poor developmental outcomes. Full study: http://nej.md/2BG0k1H Watch more Quick Take videos: http://nej.md/quick-take
Views: 4374 NEJMvideo
Preventive Therapy for Chronic Migraine
Patients with chronic migraine have functional impairment and reduced quality of life. Preventive treatment is recommended but may be underused or ineffective. New research findings are summarized in this short video. Full study: http://nej.md/2zzU0Ve Watch more Quick Take videos: http://nej.md/quick-take
Views: 3433 NEJMvideo
Notable Articles of 2018: Highlights from Editor-in-Chief Jeffrey Drazen
Editor-in-Chief Jeffrey M. Drazen, M.D., previews the Notable Articles of 2018 published in the New England Journal of Medicine: the ASPREE and PALISADE trials. Access the complete article collection at http://www.nejm.org/nejm-special Articles highlighted in video: Effect of Aspirin on Disability-free Survival in the Healthy Elderly (ASPREE trial) https://nej.md/2NDJ5nF AR101 Oral Immunotherapy for Peanut Allergy (PALISADE trial) https://nej.md/2DmlwdK
Views: 3332 NEJMvideo
Uninterrupted Dabigatran versus Warfarin for Ablation in Atrial Fibrillation
Catheter ablation is an invasive procedure; patients usually receive periprocedural anticoagulants for several weeks. New research findings are summarized in this short video. Full study: http://nej.md/2nsLuSz Watch more Quick Take videos: http://nej.md/quick-take
Views: 3628 NEJMvideo
Treating Hemophilia A
Treatment of hemophilia A, an inherited bleeding disorder, includes infusions that may result in the development of antibodies that can inhibit efficacy and increase morbidity. New research findings are summarized in a short video. Full study: http://nej.md/2txE17T Watch more Quick Take videos: http://nej.md/quick-take
Views: 8276 NEJMvideo
Increase of Telomere Length by a Sex Hormone
Telomeres shorten with DNA replication, and shorter telomeres are linked to disease. Androgenic hormones regulate expression of the telomerase gene. Would treatment with synthetic androgen slow the shortening of telomeres? New research findings are summarized in this NEJM Quick Take video. Learn more at http://nej.md/1WoeHdF
Views: 2600 NEJMvideo
Influenza and Acute Cardiovascular Events
Several studies have advanced the hypothesis that influenza may trigger acute cardiovascular events, but most were underpowered or limited by inaccurate diagnostic methods or had designs that were susceptible to bias. New research findings are summarized in this short video. Full study results: http://nej.md/2DCGCG4
Views: 3269 NEJMvideo
Treating Hereditary Angioedema
Hereditary #angioedema is characterized by recurrent episodes of swelling that can be life-threatening. Learn more: https://nej.md/2LGZRRQ Browse the full Quick Take video archive: http://nej.md/quick-take
Views: 2582 NEJMvideo
Cardiovascular Outcomes in Patients with Diabetes
Studies have shown the importance of intensive glucose lowering, blood-pressure control, and use of statins to reduce cardiovascular risk and mortality in patients with diabetes, but long-term trends in such patients are unknown. Full study: http://nej.md/2o6mCzN Watch more Quick Take videos: http://nej.md/quick-take
Views: 2359 NEJMvideo
Improving Outcomes in Spinal Muscular Atrophy
Spinal muscular atrophy is a progressive motor neuron disease with an onset during infancy that results in failure to meet motor milestones and in death or the need for mechanical ventilation by 2 years of age. New research findings are summarized in this short video. Full study: http://nej.md/2il5Jjg Watch more Quick Take videos: http://nej.md/quick-take
Views: 3501 NEJMvideo
Shorter Antibiotic Treatment for Otitis Media
Acute otitis media is the most common indication for which U.S. children receive antibiotics, usually for 10 days. Given growing concern about antimicrobial resistance, can treatment duration be shortened without changing outcomes? New research findings are summarized in a short video. Read the full study: nej.md/2hSUhgj
Views: 4829 NEJMvideo
Peripheral Nerve Blocks for Hand Procedures
This video describes how to administer a peripheral nerve block. Its primary use is to aid the treatment of hand lacerations. This procedure can also be used for other conditions, including dislocations, paronychia, and felon drainage. Watch the full video: https://nej.md/2LWEbxm
Views: 1844 NEJMvideo
Catheter-Associated UTI Prevention
Indwelling urinary catheters are commonly used in hospitals and can lead to preventable catheter-associated UTI. How can rates of catheter-associated UTI be reduced in hospitals? New research findings are summarized in a new NEJM Quick Take. Learn more at http://nej.md/1WoeHdF
Views: 8854 NEJMvideo
Body Positioning after Acute Stroke
Small, nonrandomized studies have shown that body positioning after an acute stroke may affect outcomes. New research findings are summarized in this short video. Full study: http://nej.md/2sAPwuU Watch more Quick Take videos: http://nej.md/quick-take
Views: 4064 NEJMvideo
Glutamine to Treat Sickle Cell Disease
Acute pain crises reduce quality of life and increase the risk of death in patients with sickle cell disease. Treatment with L-glutamine may lower the incidence of pain crises. Full study: https://nej.md/2LtGXuD Watch more Quick Take videos: http://nej.md/quick-take
Views: 2166 NEJMvideo
Antiinflammatory Therapy and Cardiovascular Events
Canakinumab targets a proinflammatory cytokine implicated in the development of atherothrombotic plaques. Whether reducing inflammation without lowering cholesterol would prevent cardiovascular events is unclear. New research findings are summarized in this short video. Full study: http://nej.md/2wrjwxP Watch more Quick Take videos: http://nej.md/quick-take
Views: 2421 NEJMvideo