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Total Synthesis of Reserpine - R.B. Woodward
 
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Please consider supporting the channel on Patreon! https://www.patreon.com/SupremeScience Dr. Andrew Grant covers the Total Synthesis of Reserpine as described R.B. Woodward. Enjoy! Music by the wonderful Nathaniel Schroeder. https://soundcloud.com/drschroeder © ® The Nobel Foundation.
Views: 20131 Supreme Science
38. Review: Synthesis of Cortisone
 
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Freshman Organic Chemistry II (CHEM 125B) Discoverers of the structure and biological activity of steroid hormones won seven Nobel Prizes between 1927 and 1975. Studying the steps involved in Woodward's 1951 "total" synthesis of cortisone provides a review of the organic reactions covered this semester. Many steps involved novel insights, others were based on lore from previous work In the area. The overall yield of such sequential syntheses is typically much lower than that of convergent syntheses. Practical syntheses of cortisone were based on modification of related steroids readily available from nature. Milestones in total synthesis include both purely intellectual work with natural products and commercially important synthesis of designed pharmaceuticals. The course ends with thanks to those, young and old, who have taught us all. 00:00 - Chapter 1. Steroids and the Medicinal Activity of Cortisone 07:43 - Chapter 2. Woodward's Total Synthesis of Cortisone 33:27 - Chapter 3. Practical Synthesis of Cortisone 38:59 - Chapter 4. Some Milestones in Organic Synthesis 44:59 - Chapter 5. Thanks to Teachers, Colleagues, Family, and Students Complete course materials are available at the Open Yale Courses website: http://oyc.yale.edu This course was recorded in Spring 2011.
Views: 9641 YaleCourses
The Quest To Make Any Molecule: Total Synthesis with Hosea Nelson - Speaking of Chemistry
 
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Speaking of Chemistry caught up with UCLA’s Hosea Nelson to learn about how chemists are trying to copy nature for a brighter future. Don’t forget to subscribe: http://bit.ly/ACSReactions ↓↓More links and references below↓↓ Check out the Talented 12 website for everything you need to know about the T12, including a form to nominate next year’s distinguished dozen: http://talented12.cenmag.org/ Don’t forget to read our full story on Hosea: http://talented12.cenmag.org/hosea-nelson/ And yes. People really do call them deadly carrots: https://phylofadb.bch.msu.edu/plants/10488 Additional resources Chemists Find More Efficient Total Synthesis Route To Ingenol | C&EN http://cen.acs.org/articles/91/i51/Chemists-Find-Efficient-Total-Synthesis.html Multi C–H Functionalizations | C&EN http://cen.acs.org/articles/93/i38/Multi-CH-Functionalizations.html Natural Products as Sources of New Drugs from 1981 to 2014 | Journal of Natural Products http://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.5b01055 Speaking of Chemistry is brought to you by Chemical & Engineering News, the news magazine of the American Chemical Society. Find us on all these places: Subscribe! http://bit.ly/ACSReactions Facebook! http://facebook.com/SpeakingOfChem Twitter! http://twitter.com/ACSReactions Tumblr! http://tumblr.com/ACSReactions Music is "Funk Soul Summer" by waggstar
Views: 8874 Reactions
4/1/17 Timothy Newhouse - Not for Fools: Organic Synthesis of Natural Products
 
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Speaker: Timothy Newhouse (Yale Chemistry) Making the materials and therapeutics of the future, synthetic chemists synthesize and discover new molecules by twisting bonds and stereocenters at their will. Come join us to learn from Professor Tim Newhouse how the real Walter Whites of the world manipulate organic molecules to get rich. Science Saturdays is a special lecture series designed for families that brings the excitement of research and the passion of scientists to the community. Each event involves a lecture by a Yale professor and hands-on science demonstrations run by Yale College students. Bring the whole family! For more event information, go to: www.yale.edu/scienceoutreach.
Views: 1240 YaleUniversity
Total Synthesis of a Natural Product - Dance Your PhD
 
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An explanation of why it is important for organic chemists to synthesize biologically active naturally occurring molecules and a simplified representation of how that is done. Often time biologically active naturally occurring molecules are not abundant in nature and therefore nature is not a feasible source. Organic chemists are able to synthesize these molecules in labs and make them more abundant. As a synthetic organic chemist I am able to make chemicals that nature can’t make enough off. So you can think of us as builders on the molecular level. As a total synthetic chemist, I figure out how pieces fit together, what conditions you might need to make two molecules react (or connect) with one another. Sometimes molecules just don't react with one another. Some molecules are temperature sensitive and sometimes molecules just need a little push from a catalyst or activator to get the reaction to occur.
Views: 2878 DanceChemistry
Saxitoxin: CIA Chemical Weapons, Biochemistry and Total Synthesis (Kishi, Jacobi, Du Bois)
 
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Long time no see! I hope you all have been doing better than me in my army bootcamp. This video deals with the history and use of the marine natural product saxitoxin as a chemical weapon, its biochemistry and most importantly, strategies towards its total synthesis. I hope to rejuvenate this channel and make more videos in the future, so please show your support and like & subscribe them. If you have any suggestions on what I should talk about next, the format or difficulty level of the videos or general tips on how to improve, share them with me in the comments. 00:00 Some comments on what I've been up to 00:58 History of saxitoxin and it's use in CIA operations 02:34 Medicinal background saxitoxin (paralytic shellfish poisoning, PSP) and short overview of mechanism of action (sodium channel blocker) 05:39 Retrosynthesis and strategy employed by Yoshito Kishi in 1977: Oldschool organic chemistry and electrocyclizations 07:42 Retrosynthesis and strategy employed by Peter Jacobi in 1984: Dipolar azomethine ylide cycloadditions and radical chemistry 09:37 Retrosynthesis and strategy employed by Du Bois in 2006: Modern C-H functionalization and oxidations References: Kishi: https://pubs.acs.org/doi/abs/10.1021/ja00450a079 Jacobi: https://pubs.acs.org/doi/abs/10.1021/ja00331a032 Du Bois: https://pubs.acs.org/doi/abs/10.1021/ja071501o Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of reactions and applications thereof with common conditions) - Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
Views: 887 Total Synthesis
Total Synthesis of Longifolene
 
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In this video you will find a brief overview of the total synthesis of longifolene. Each reaction is discussed in detail. Youtube Channel (Hindi) - https://www.youtube.com/channel/UCmIchtf7_PvcAOfT5p5f6eQ Unacademy - https://unacademy.com/user/Sethi Disclaimer The information provided on this channel is a public service with the understanding that Gate Chemistry makes no warranties, either expressed or implied, related to completeness, accuracy, reliability or suitability of the information. The channel disclaims liability for errors and omissions that may have crept in its content.
Views: 1847 Gate chemistry
3JohnWood
 
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John Wood (Baylor) Recent Progress in the Synthesis of Complex Natural Products - Phomoidride D Part of the Harry Wasserman Memorial Symposium at http://chem.yale.edu/HHW
Views: 916 Mike McBride
How to Design a Total Synthesis
 
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In this video, I include footage from a lecture I delivered teaching students the basic principles of how to design a total synthesis of a molecule, focusing on retrosynthetic analysis.
Views: 16691 Mike Christiansen
Chemistry Is All About Perspective - Twistane Total Synthesis
 
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Please consider supporting the channel on Patreon! https://www.patreon.com/SupremeScience In this video, Dr. Andrew Grant explores how looking at target molecules in different light, give new insight into Organic Synthetic Strategies. He achieves this by tackling the total synthesis and history of a unique molecule, Twistane. Enjoy! Music by the wonderful Nathaniel Schroeder. https://soundcloud.com/drschroeder
Views: 4436 Supreme Science
ShareBiotech | Paul Murphy, NUIG | The Chemistry Of Natural Products
 
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3 Sep 2012; Athlone Institute of Technology hosted presentations concerning new technologies in Natural Products. The meeting was focused on SME members of the Natural Products Biotechnology sector in Ireland a sought to clearly identify company perceptions of deficits regarding partnerships, collaborations, access to core facilities, required skills, training and effective networking within Ireland, the Atlantic Region of the EU and beyond.
Views: 2047 Sixsem
The Art of Chemical Synthesis
 
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The Center for Selective C-H Functionalization (CCHF) is leading a paradigm shift in the art of organic synthesis by bringing together experts from across a broad range of chemical disciplines. This collaborative network has an equally broad geographical distribution, with institutes from across the United States. http://nsf-cchf.com
Views: 16673 Emory University
Total Synthesis of Ginkgolide B
 
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Update!! Finally, I have made a video of Ginkgolide B with commentary. You can check out part 1 here: https://youtu.be/V76kv4hO3WQ and part two here: https://youtu.be/Ish0ld3Oi0o Part one of the Total Synthesis of Ginkgolide B Music by Kevin MacLeod (The Descent)
Views: 2144 OrganicChemistOnCall
Natural Product Discovery
 
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Associate Professor Thomas Ostenfeld Larsen, who heads the research group Natural Product Discovery at DTU Systems Biology talks about the group’s discovery and engineering of novel natural products from an array of organisms. Products that may be used to solve some of the challenges society face today. One example is a very large project where they sequence all known species in genus aspergillus. This will give them first hand access to genomics driven discovery of silent gene clusters and engineering of these to produce the potentially new drug lead candidate of the future.
Views: 682 Mette Haagen
100 Years of Natural Product Synthesis Mobile
 
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History of Organic Chemistry at the Helsinki University of Technology Chemistry Deparment starting form Komppa to 2003
Views: 356 Ari Koskinen
Organic Chemistry Walkthrough Steroid Synthesis: History, Retrosynthetic Strategies, Mechanisms
 
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In this video we will talk about the total synthesis of steroid hormones in the early 20th century. After an introduction into the history of steroids and challenges with steroid and natural product isolation, we will go through the retrosynthetic analysis Welcome to this channel around the topic of organic synthesis. This is not an experimental channel showcasing chemical experiments but rather will deal with theoretical discussions of syntheses of important chemicals and interesting natural products. If you are not familiar with organic chemistry, do not expect to understand everything I'm talking about. Please consult the literature, the myriad of youtube videos about basic chemistry or just Google. Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of reactions and applications thereof with common conditions) - Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
Views: 792 Total Synthesis
First Asymmetric Total Synthesis of Pleurospiroketals!
 
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Pleurospiroketals-A is a Sesquiterpenoids and Cytotoxic against HeLa cancer cells.
Views: 13 Dipak sarkar
Synthesis of Lysergic Acid (LSD Precursor): History, Strategies, Mechanisms (Hofmann, Woodward)
 
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Please excuse some slight audio pops; I'll keep in mind to keep the mic further away next time. Welcome to this channel around the topic of organic synthesis. This is not an experimental channel showcasing chemical experiments but rather will deal with theoretical discussions of syntheses of important chemicals and interesting natural products. If you are not familiar with organic chemistry, do not expect to understand everything I'm talking about. Please consult the literature, the myriad of youtube videos about basic chemistry or just Google. In this first video, we will cover the history of lysergic acid, a LSD precursor, its first total synthesis and a modern approach (with increasing difficulty). I threw in some sidenotes and anecdotes to make the material slightly less dry. 00:00 Introduction about the significance of lysergic acid derivatives and importance of natural products 00:49 Overview 02:09 History preceding the synthesis of lysergic acid about the work of Albert Hofmann at Sandoz (first semisynthesis) 04:12 First total synthesis by chemists at Lilly & Nobel laureate Robert Burns Woodward. This synthesis employs reactions encountered at in the first two years at an undergrad level. 12:40 Modern approach by Prof. Ohno at Kyoto University. This contemporary synthesis relies on organometallic chemistry and more advanced retrosynthetic disconnections. This part contains a short discussion of reaction mechanism. 18:10 Closing comments Tell me whether I should continue doing such videos and if so, whether I should focus on "easy" approaches or more advanced ones (or make two types of videos and do both of them). Subscribe and like this video if you want to show your support. Albert Hofmann's notes: http://www.psychedelic-library.org/hofmann.htm Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of reactions and applications thereof with common conditions) - Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
Views: 14856 Total Synthesis
CHEM253L Week 8: Synthesis of a Fluorescent Natural Product Pre-Lab Video
 
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CHEM253L Organic Chemistry III Rose-Hulman Institute of Technology Prof. Ross Weatherman
Views: 1101 Rose-Hulman Online
[Wikipedia] Total synthesis
 
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Total synthesis is the complete chemical synthesis of a complex molecule, often a natural product, from simple, commercially available precursors. It usually refers to a process not involving the aid of biological processes, which distinguishes it from semisynthesis. The target molecules can be natural products, medicinally important active ingredients, or organic compounds of theoretical interest. Often the aim is to discover new route of synthesis for a target molecule for which there already exist known routes. Sometimes no route exists and the chemist wishes to find a viable route for the first time. One important purpose of total synthesis is the discovery of new chemical reactions and new chemical reagents. https://en.wikipedia.org/wiki/Total_synthesis Please support this channl and help me upload more videos. Become one of my Patreons at https://www.patreon.com/user?u=3823907
Views: 4 WikiTubia
Dr. Yang, Total Synthesis Complex Natural Anti-cancer compound Taxol, Structure Modification lab.
 
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AZ Nature Art (www.aznpbio.com) ​9285 Dowdy Drive, Suite 103 San Diego, CA 92126 [email protected]; Tel: 360-464-3767 What We Can Do: Authentic identification of ethnomedicinal plants associated with common names, folk and historic uses, scientific definitions, description, likely alterations and synonyms Geographic distribution and abundance analysis Biological study and Efficacy review Raw material evaluation and sourcing (vendor audit and price investigation, available ingredient and extract purity, strength, composition, active compounds and content range) Comparison and selection of functional plants and ingredients for product formulation Safety evaluation including acute and chronic toxicities, LD50, effects on infants and reproductive organs Irritation and allergy assesment Dosage range suggestion Novelty assessment and patent claims construction Assessment and prediction of oral availability and tissue distribution Quality control method design (UV, HPLC, TLC, HPTLC, GC or GC/MS, organic solvent residues, microbial, heavy metals, and pesticides in standardized extract, compound and ingredient) Manufacturing methods We also supply herbs, raw materials, authentic extracts and cutting-edge science-based functional ingredients. AZNPbio is a San Diego, California (CA) based, privately-held bio-tech company engaged in natural product sourcing, collection, extraction, purification and manufacturing to serve health product company’s ever-growing new target and ingredient developments. We have operations and collaborations in US and China. Our library includes more than 8000 bio-collections from over 3500 genera. Currently 5000 extracts purified from 3000 plant species, and 7000 HPLC-isolated compounds and fractions are ready for bio-active screening. One-third of our collections have origin from the Middle East and Africa. With samples derived from lichen, liverwort, fern, algae, mushroom, aquatics, marine, worm, higher plants and insects for bio-screening (HTS), generating hit-to-lead and preclinical candidates; AZNPbio can help grow your R&D pipeline of new drugs, cosmetics, preservatives, natural flavors, herbcides and pesticides.
Views: 171 Jeff Zhao
Biosynthesis of polyketide natural products
 
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Biosynthesis of polyketide natural products; Chapters: 0:00 - Introduction; 00:45 - Aims and objectives; 04:45 - Biosynthesis of natural products; 08:00 - Biosynthesis of natural products; 10:00 - Making the polyketide chain; 15:45 - Coenzyme A; 29:30 - The missing link; 32:15 - Folding of the poly-beta-ketoester (C-C bond); 40:15 - Claisen or aldol;
Views: 15040 DTUdk
Legal high from moss better than medical cannabis? History, Biology, Synthesis of THC, CBD & PET
 
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Hey guys, I'm back with another video! This time, we will cover the basics of cannabinoids. We'll discuss the history, biochemistry, pharmacology and total synthesis of these highly useful natural products. Recent research is used as an example of the importance and potential of cannabinoids in medicine. This video does not endorse the preparation of illegal substances. No detailed steps or procedures for syntheses of illegal drugs are discussed. I hope it's clear that here we focus on fascinating aspects of science and on the potential that compounds have in improving the lives of patients. 00:00 Introduction of medical cannabinoids; Applications of cannabidiol (CBD) and tetrahydrocannabinol (THC) for treatment of epilepsy and other conditions; Introduction of legal high of liverwort 04:35 History and Isolation of THC; Discovery of the endocannabinoid system, endocannabinoid receptors (CB1 and CB2) and endocannabinoids anandamide and arachidonylglyceride; CB1 antagonists as anti-obesity drugs; Total synthesis of THC and CBD by Raphael Mechoulam at the Weizmann Institute 15:18 Can you get legally high from moss or liverwort? Summary of pharmacological results from the key paper, based on work of Professor Gertsch and co-workers at the University of Bern; Tetrad test, Prostaglandins; Implications for medicinal applications 21:32 Organic synthesis and two total syntheses of cis-perrottetine by Professor Carreira at ETH Zürich (2018) and Professor Kim at Seoul University (2008); Discussion of key steps and synthetic strategies and reaction mechanisms 28:17 Closing remarks Mechoulam interview/documentary: - The Scientist (2015): https://www.youtube.com/watch?v=fu6FhJIyTEc Liverwort paper: - Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high (Science Advances 2018, 4, 2166): http://advances.sciencemag.org/content/4/10/eaat2166 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of reactions and applications thereof with common conditions) - Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
Views: 2063 Total Synthesis
7 Partial and Total Synthesis ch3 12th
 
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https://youtu.be/J38wIFmH26w https://youtu.be/J38wIFmH26w https://youtu.be/J38wIFmH26w
Partial and Total Synthesis
 
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Chemistry_c-9-10-org-chem-68.mp4
Views: 2997 Sabaq. Pk
Natural product chemistry | Wikipedia audio article
 
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This is an audio version of the Wikipedia Article: https://en.wikipedia.org/wiki/Natural_product 00:02:17 1 Classes 00:03:16 2 Function 00:04:36 2.1 Primary metabolites 00:08:23 2.2 Secondary metabolites 00:10:05 3 Biosynthesis 00:10:56 3.1 Carbohydrates 00:12:06 3.2 Fatty acids and polyketides 00:13:27 4 Sources 00:15:49 4.1 Prokaryotic 00:15:58 4.1.1 Bacteria 00:18:11 4.1.2 Archaea 00:19:30 4.2 Eukaryotic 00:19:39 4.2.1 Fungi 00:20:55 4.2.2 Plants 00:22:21 4.2.3 Animals 00:25:20 5 Medical uses 00:26:11 5.1 Traditional medicine 00:27:00 5.2 Modern natural product-derived drugs 00:30:22 5.3 Limiting and enabling factors 00:31:56 6 Isolation and purification 00:35:19 7 Synthesis 00:37:45 7.1 Semisynthesis 00:40:01 7.2 Total synthesis 00:41:10 7.3 Symmetry 00:42:29 8 Research and teaching 00:43:07 8.1 Chemistry 00:44:38 8.2 Biochemistry 00:45:09 9 History 00:45:18 9.1 Foundations of organic and natural product chemistry 00:46:06 9.2 Isolation 00:47:37 9.3 Synthesis 00:50:35 9.4 Structural theories 00:52:32 9.5 Expanding the concept 00:53:33 9.6 Milestones 00:55:15 10 See also 00:55:37 10.1 Journals Listening is a more natural way of learning, when compared to reading. Written language only began at around 3200 BC, but spoken language has existed long ago. Learning by listening is a great way to: - increases imagination and understanding - improves your listening skills - improves your own spoken accent - learn while on the move - reduce eye strain Now learn the vast amount of general knowledge available on Wikipedia through audio (audio article). You could even learn subconsciously by playing the audio while you are sleeping! If you are planning to listen a lot, you could try using a bone conduction headphone, or a standard speaker instead of an earphone. Listen on Google Assistant through Extra Audio: https://assistant.google.com/services/invoke/uid/0000001a130b3f91 Other Wikipedia audio articles at: https://www.youtube.com/results?search_query=wikipedia+tts Upload your own Wikipedia articles through: https://github.com/nodef/wikipedia-tts Speaking Rate: 0.7423677073622912 Voice name: en-GB-Wavenet-B "I cannot teach anybody anything, I can only make them think." - Socrates SUMMARY ======= A natural product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical synthesis (both semisynthesis and total synthesis) and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets. The term natural product has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients.Within the field of organic chemistry, the definition of natural products is usually restricted to mean purified organic compounds isolated from natural sources that are produced by the pathways of primary or secondary metabolism. Within the field of medicinal chemistry, the definition is often further restricted to secondary metabolites. Secondary metabolites are not essential for survival, but nevertheless provide organisms that produce them an evolutionary advantage. Many secondary metabolites are cytotoxic and have been selected and optimized through evolution for use as "chemical warfare" agents against prey, predators, and competing organisms.Natural products sometimes have therapeutic benefit as traditional medicines for treating diseases, yielding knowledge to derive active components as lead compounds for drug discovery. Although natural products have inspired numerous U.S. Food and Drug Administration-approved drugs, drug development from natural sources has received declining attention by pharmaceutical companies, partly due to unreliable access and supply, intellectual property concerns, seasonal or environmental variability of composition, and loss of sources due to rising extinction rates.
Views: 45 wikipedia tts
Search for and synthesis of natural organic compounds with unique structures and functions
 
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The Nakata-Saikawa Research Lab in the Department of Applied Chemistry at Keio University’s Faculty of Science and Technology conducts research on organic chemistry of natural products. Q. The natural world has many mysterious phenomena and ingenious tricks that we would never think of. By synthesizing challengingly complex structured organic compounds, or by explaining the nature of yet to be understood mysterious organic phenomena at the molecular level, we think we can discover new compounds, new properties of compounds, and new organic chemical reactions. The Nakata-Saikawa Research Lab has been conducting synthesis research targeting natural organic compounds with complex and unique structures. As part of this research, during the synthesis of the ansa compound kendomycin, under a new method using the Dotz reaction to form an aromatic core while simultaneously generating a ring, the lab has successfully synthesized abundantly varied ansa compounds that cannot be created in the natural world. Q. Ansa compounds have interesting structures so they are fun to make, and quite a variety of bioactive compounds are produced, so in fact some are used in medicines. Of these, kendomycin is a compound that relatively recently was isolated and had its structure determined. From that time it was being targeted by synthetic chemists. We too have focused on synthesizing kendomycin, which may become a lead compound of pharmaceutical drugs, in an interesting manner. In addition to the synthesis of compounds, the Nakata-Saikawa Research Lab is focused on physiological phenomena and natural phenomena in organisms, conducting research to extract related organic compounds. Among this is research on a chemical substance that causes sneezing. Q. There is a red striped jellyfish called chrysaora pacifica. When it gets caught in a fishing net and turns into a powder after becoming dried out and stale, it has long been said that people will sneeze uncontrollably just by passing by it. What is it that causes the sneezing? It is something that causes everybody to sneeze, so to figure out what it is, we caught some chrysaora pacifica and made it into a powder. Using mice, we are administering a sample in their noses and counting the number of sneezes as a method to discover the inducing substance. At this point it appears that the substance is very unstable. It is not as if we understand its structure yet, but we have started to see that the substance causing the sneezing is something unique, so we think this research has become interesting. In addition, the Nakata-Saikawa Research Lab is also conducting fascinating research to explain the mechanisms of biological phenomena. This includes extracting compounds involved in the phenomenon of the calcium in an egg shell moving to the bones of a chick when the chick grows inside the egg. Q. When you look around there are many interesting natural phenomena. Look at the various things around you and give it some thought as to how in the world they became like that. When you do this, you will discover that there are still many extremely interesting unexplained phenomena. If we continue to work hard researching to explain them, I think we will definitely discover some interesting science, so I want everyone to join the world of science.
1  structure elucidation of natural products- Classical chemical methods
 
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My 1st lecture in the spectroscopy series. It deals mostly with structure elucidation of natural products and its significance. Classical chemical methods of structure analysis, its advantages and disadvantages are discussed.
bio synthesis english Polyketides and mono-terpene and natural products
 
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In this tutorial I explained the introduction of biosynthesis of Polyketides and mono-terpene for beginner. How various molecules are synthesizes in nature pathway. mono-terpene can be synthesized by rearrangement of one important carbocation. The path of mono-terpene, sesquiterpene, diterpene is explained in this lesson. Various reaction like Ester condensation, aldol reaction rearrange reaction in nature leads to synthesis of natural Products. in this lesson how natural product synthesized in nature and how biosynthesis done or occur. bio synthesis is an important branch of organic chemistry
Views: 2674 Ocean of knowledge
Zhendong Jin Associate Professor PhD
 
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Dr. Jin researches the total synthesis of biologically active natural products & structural analogues, development of new synthetic methods with interest in asymmetric reactions, & synthesis of small libraries with the aim of anticancer drug discovery.
Views: 501 MNPCUI
How to Choose a Synthesis Target and Search Current Literature (2013)
 
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In this video, I will teach you how organic chemists go about finding molecules to synthesize using current scientific literature, specifically including the Journal of Natural Products.
Views: 1511 Mike Christiansen
6 Plants and Natural Products Chemistry ch3 12th
 
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https://youtu.be/C0HYJtRVBpA https://youtu.be/C0HYJtRVBpA https://youtu.be/C0HYJtRVBpA
Natural Product Chemistry
 
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A student in the research group of Armen Zakarian shows us the solvent stills that are used during her work.
Views: 1933 UCSBchemistry
Carl Djerassi - Working on natural products of chemistry (82/117)
 
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To listen to more of Carl Djerassi’s stories, go to the playlist: https://www.youtube.com/playlist?list=PLVV0r6CmEsFwKnZJAXj6a3kZfe4rn_riG Austrian-American Carl Djerassi (1923-2015) was born in Vienna. He revolutionised the field of female contraception when he and his team of chemists produced synthetic progesterone which led to the development of the first oral contraceptive pill. [Listener: Tamara Tracz] TRANSCRIPT: In Mexico I was entirely a synthetic chemist, I was making things with an object to make them, so that they can be used for medicinal purposes, mostly by synthetic chemists, but the cacti, it really started with that. I just developed a curiosity of what’s in it, and that led me to start working on cactus chemistry, and very few people worked on cactus chemistry, there was really only one natural product that was famous, if not notorious, and that was mescaline from peyote buttons, but these were small cacti. They were from Mexico, but they were small, and not the really giant treelike ones here, and so I focused on that and we did- I probably did, maybe a dozen PhD thesis’s, and many post docs who worked on the constituents of giant cacti, and we did some very important work. And it had no- there were no practical consequences of this, and I didn’t even mean there to be, but chemically they were extremely interesting, and that led me also to alkaloid work, and to- what I really found were interesting, triterpines, and triterpines are compounds that look like, like steroids, but are even more complex. I don’t know whether I have some- I may have some structures in here? No, probably not. Chemical structures, but I worked on these, and that led me to alkaloid chemistry, and that led me to antibiotic chemistry, but it led me to the structure elucidation of compounds, rather than to the synthesis of it. And structurally I’ll use, not quite an architectural metaphor, which you try to use for synthesis, to try and draw the difference between total synthesis and partial synthesis, but a different one, and at that time it was, I think for me, intellectually an even more challenging one, and it was something which was primarily practised in Europe, and later also in Japan, and much less so in the United States, which sort of, continued my sort of outside status I mentioned, even in, in chemical priorities. Namely, natural products of chemistry means to identify the chemical structure of chemicals in natural products, and that was the first priority, and the next one was what could you use them for, or why are they there, and then finally, even how are they synthesised by that plant or animal? Most of them were plants at that time. The analogy is that you walk into a pitch dark room, a furnished room, and you want to find out what is in this room, and by that I mean what sort of furniture, and initially, just are there tables, beds, chairs, what are they made out of, what are their shapes, what are their colours, and so on and so forth? And in the end, how are they made, why are they made, why is that there, assuming that you don’t even know what a chair is, and a table? Now, how would you do that if you go in a pitch-dark room and you have nothing? All you can do is grope around and you feel with your fingers, and sometimes you can be grossly misled, and sometimes you wouldn’t be. This is a good example, this table here, which is oval. Well, you know, when you feel it around you would not necessarily think that this is actually a table, and even the material is an unusual material for a table. This happens to be metal, and most dining room tables are not really metal like this, and it wouldn’t feel that way, so you could already be misled if you just did it by feeling, although eventually you might be able to figure it out. Well, the next thing you do is you try and at least light a match, and when you light a match you can really illuminate only very little, and for only a very short period of time, so you have to either light a lot of matches and do it gradually, and then discover it, or maybe if you are lucky you can try and get a candle, and then you can see more, and maybe a flashlight, and so on. Now, of course the ideal thing would be if you would take a photograph, and in fact, if you take a colour photograph then you’ve got everything there. With one photograph with a wide angle lens you take the entire room, you see it right there, and you even see it in colour, and then you can already extrapolate very much what the materials are there, although not necessarily entirely, so that’s exactly what natural product chemistry is. You want to know what is in that particular plant, let us say, but.... Read the full transcript at https://www.webofstories.com/play/carl.djerassi/82
Natural Products
 
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Chemical and Spectral approach to Natural Products In early time, element detection , percent composition and determining its empirical formula Modern technique: Includes six inquiries: Physical properties Classification by solubility Classification tests by functional groups Chromatographic analysis Spectroscopic analysis Synthesis of solid derivatives
A Second-Generation Synthesis of the Cyanthiwigin Natural Product Core
 
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Kelly Kim, a Graduate Student from the Stoltz Lab, at Caltech, describes the latest CCHF Publication.
Total Synthesis of Belizentrin Methyl Ester
 
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work by Alois Fürstner and colleagues, Max Planck Institute for Coal Research, Mülheim, Germany, published in Angewandte Chemie https://www.chemistryviews.org/details/ezine/11082120/Total_Synthesis_of_Belizentrin_Methyl_Ester.html
Lecture 2: Citral
 
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Structure determination of citral, reactions and synthesis of citral, NMR of citral, cis-trans isomerism in citral
Views: 4168 Nandkishor Karade
Progress in the Chemistry of Organic Natural Products is Celebrating 80 Years
 
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The Springer book series Progress in the Chemistry of Organic Natural Products was started in 1938 by Laszlo Zechmeister. 80 years and 107 volumes later we are celebrating a legacy that has resulted in the “Zechmeister” becoming one of the premier book series in the field. Explore how the series has developed, the people behind the scenes and submit your proposal to become part of this series’ story! Learn more about the iconic book series here: https://www.springer.com/series/10169
Views: 145 Springer Nature
[Wikipedia] Nicolaou Taxol total synthesis
 
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The Nicolaou Taxol total synthesis, published by K. C. Nicolaou and his group in 1994 concerns the total synthesis of Taxol. This organic synthesis was included in Nicolaou's book, 'Classics in Total Synthesis'. Taxol is an important drug in the treatment of cancer but also expensive because the compound is harvested from a scarce resource, namely the pacific yew. This synthetic route to Taxol is one of several; other groups have presented their own solutions, notably the group of Holton with a linear synthesis starting from borneol, the Samuel Danishefsky group starting from the Wieland-Miescher ketone and the Wender group from pinene. The Nicolaou synthesis is a good example of convergent synthesis because the molecule is assembled from 3 pre-assembled synthons. Two major parts are cyclohexene rings A and C that are connected by two short bridges creating an 8 membered ring in the middle (ring B). The third pre-assembled part is an amide tail. Ring D is an oxetane ring fused to ring C. Two key chemical transformations are the Shapiro reaction and the pinacol coupling reaction. The overall synthesis was published in 1995 in a series of four papers in the Journal of the American Chemical Society. https://en.wikipedia.org/wiki/Nicolaou_Taxol_total_synthesis Please support this channel and help me upload more videos. Become one of my Patreons at https://www.patreon.com/user?u=3823907
Views: 499 WikiTubia
Development of New Useful Substances Producible from Chemical Reactions of Organic Compounds
 
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The Takao Laboratory of Keio University's Faculty of Science and Technology Department of Applied Chemistry is engaged in the research and development of artificially creating various organic compounds extracted from natural sources. Q. "As its name implies, natural products are organic compounds found in nature, but I don't mean seaweed like wakame or kombu. People have been discovering substances useful to humankind from nature such as those used in many medications. We are using chemical reactions to synthesize compounds also beneficial to people without relying on living organisms. Another research theme as one of our two main areas of research is the development of synthesis reactions." The Takao Laboratory is conducting research in two main areas with the goal of producing new organic compounds useful to people. One is "research on synthesis of natural products" in which an inexpensive starting substance is chemically converted into compounds useful to living beings, and the other is "development of new organic synthesis reactions" in which chemical reactions of organic compounds are elicited by various conditions. Included in this research are skeletal transformation reactions and efficient catalyst reactions. Q. "The skeleton of organic compound is made of carbon, and for example there are square four-membered rings, namely cyclobutane rings. By using a metal catalyst, the cyclobutane can be changed into what is called cyclopentane. We have been successful in developing chemical reactions that transform skeletal structures. During this process, a catalytic reaction is one in which just a small amount of metal and organic catalyst are used in such reactions and the catalyst spins round and round. We are also working to have this result in skeletal transformation." The Takao Laboratory also conducts research on antitumor and antibacterial substances found in nature. Q. "Naturally occurring microbes are not producing things with the intention of curing cancer in humans, but the result is that they are producing compounds that destroy cancer cells. As for current drugs, it is not as if humans have completely defeated cancer. Through the efforts of people to date, various anticancer drugs have been developed, but I think it's still not nearly enough. I think that synthetic organic chemistry is needed after all to develop scientists who will create new drugs that cure human disease." Through numerous experiments, the Takao Laboratory is overcoming one barrier after another to enable total synthesis of new compounds useful against diseases resistant to treatment. Q. "We use the terms 'new compounds' and 'useful substances' in regard to what we are targeting as set phrases, but as to whether they are useful or not, to be honest I don't know. They are simply new. However, there may come a time some years later, maybe 50 years from now, when this compound is absolutely essential to people. It is for just such a time that we want to test the power of science to show that new compounds can also be created." Q. "As for drugs that are effective in treating cancer or Alzheimer's, there are aspects of their structure that we already know. To make them more efficient will require more efficient chemical reactions. So we always carry the hope that the reactions we are developing will be used in applications such as these."
Fisching for Marks
 
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This extremely serious documentary outlines how the Fischer Indole Synthesis works, the uses of indoles and of course, high quality interviews that is guaranteed to get full marks for our Advanced Organic Chemistry group assignment. Special thanks to Andrew Wrangell for his kind permission to use his original song Be Bold. Check out his YouTube channel Andrew Wrangell Music! https://www.youtube.com/watch?v=lEHgxgzGqdE (P.S. Andrew also runs the YouTube channel Sheet Music Boss if you also wanted to check it out: https://www.youtube.com/channel/UCzTR9iSH-TFC4-ocDS_ll4A) Also, The Kooks' song "Be Who You Are" was playing in the background for an interview. Unfortunately we had no control over this sooo... Thanks guys for letting us use your music??? References: Heravi, M.M., Rohani,  S., Zadsirjan, V., Zahedi, N. (2017). Fischer indole synthesis applied to the total synthesis of natural products. The Royal Society of Chemistry, 7, 52852-52887. doi: https://doi.org/10.1039/C7RA10716A. McIntosh, J. (2018). What is serotonin and what does it do? Retrieved from https://www.medicalnewstoday.com/kc/serotonin-facts-232248. Name Reaction. (2018). Fischer Indole Synthesis. Retrieved from https://www.name-reaction.com. Nobel Media AB. (2014). The Nobel Prize in Chemistry 1902. Retrieved from www.nobelprize.org. Pub Chem. (n.d.). Indole. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/indole#section=Top. RxList. (2018). Indole-3-carbinol. Retrieved from https://www.rxlist.com/indole-3-carbinol/supplements.htm. Science Direct. (2018). Indole. Retrieved from https://www.sciencedirect.com/topics/neuroscience/indole. Sung, W.S., Lee, D.G. (2007). The Candidacical Activity of Indole-3-Carbinol that Binds with DNA. IUBMB Life, 59(6), 408-412. Web MD. (2017). What is Melatonin? Retrieved from https://www.webmd.com/sleep-disorders/what-is-melatonin.
Views: 141 Meredith Navin

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