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4/1/17 Timothy Newhouse - Not for Fools: Organic Synthesis of Natural Products
 
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Speaker: Timothy Newhouse (Yale Chemistry) Making the materials and therapeutics of the future, synthetic chemists synthesize and discover new molecules by twisting bonds and stereocenters at their will. Come join us to learn from Professor Tim Newhouse how the real Walter Whites of the world manipulate organic molecules to get rich. Science Saturdays is a special lecture series designed for families that brings the excitement of research and the passion of scientists to the community. Each event involves a lecture by a Yale professor and hands-on science demonstrations run by Yale College students. Bring the whole family! For more event information, go to: www.yale.edu/scienceoutreach.
Views: 971 YaleUniversity
Total Synthesis of a Natural Product - Dance Your PhD
 
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An explanation of why it is important for organic chemists to synthesize biologically active naturally occurring molecules and a simplified representation of how that is done. Often time biologically active naturally occurring molecules are not abundant in nature and therefore nature is not a feasible source. Organic chemists are able to synthesize these molecules in labs and make them more abundant. As a synthetic organic chemist I am able to make chemicals that nature can’t make enough off. So you can think of us as builders on the molecular level. As a total synthetic chemist, I figure out how pieces fit together, what conditions you might need to make two molecules react (or connect) with one another. Sometimes molecules just don't react with one another. Some molecules are temperature sensitive and sometimes molecules just need a little push from a catalyst or activator to get the reaction to occur.
Views: 2796 DanceChemistry
3JohnWood
 
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John Wood (Baylor) Recent Progress in the Synthesis of Complex Natural Products - Phomoidride D Part of the Harry Wasserman Memorial Symposium at http://chem.yale.edu/HHW
Views: 810 Mike McBride
nobel prize chemistry 2015 | 2015 Nobel Prize in Chemistry | K.C. Nicolaou
 
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nobel prize chemistry 2015 Nomination K.C. Nicolaou "for his work regarding synthesis for natural products" Paclitaxel Taxol From the bark of Pacific Yew Discovered in 1964 Effective anti-cancer drug Suppressing microtubule dynamics Mitosis blocked - apoptosis Less cytotoxic & Controllable Total Synthesis 3 Key Steps Importance of Nicolaou’s approach to total synthesis High yield of paclitaxel in relative low cost Resources are more accessible & nature-friendly Improve the drug’s efficacy Better anti-cancer approach and ability Cancer Unregulated growth of cells Rapid mitosis Rapid replication of DNA Rapid dynamics of cyctoskeleton Microtubules Located throughout cytoplasm Polymer of tubulin Grow and shorten rapidly during mitosis Ideal target for anti-cancer drug Diels-Alder Reaction Addition of alkenes Key reaction in synthesizing A & C Pinacol Coupling Shapiro Reaction Synthesis of alkene from an aldehyde First bridge connecting A & C Coupling of two aldehyde groups Final step of ring B synthesis Second bridge Overview 2015 Nobel Prize in Chemistry K.C. Nicolaou Subscribe to our channel for more informative videos https://www.youtube.com/watch?v=G08lv2rVVQM
Views: 3653 infotainment
The Quest To Make Any Molecule: Total Synthesis with Hosea Nelson - Speaking of Chemistry
 
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Speaking of Chemistry caught up with UCLA’s Hosea Nelson to learn about how chemists are trying to copy nature for a brighter future. Don’t forget to subscribe: http://bit.ly/ACSReactions ↓↓More links and references below↓↓ Check out the Talented 12 website for everything you need to know about the T12, including a form to nominate next year’s distinguished dozen: http://talented12.cenmag.org/ Don’t forget to read our full story on Hosea: http://talented12.cenmag.org/hosea-nelson/ And yes. People really do call them deadly carrots: https://phylofadb.bch.msu.edu/plants/10488 Additional resources Chemists Find More Efficient Total Synthesis Route To Ingenol | C&EN http://cen.acs.org/articles/91/i51/Chemists-Find-Efficient-Total-Synthesis.html Multi C–H Functionalizations | C&EN http://cen.acs.org/articles/93/i38/Multi-CH-Functionalizations.html Natural Products as Sources of New Drugs from 1981 to 2014 | Journal of Natural Products http://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.5b01055 Speaking of Chemistry is brought to you by Chemical & Engineering News, the news magazine of the American Chemical Society. Find us on all these places: Subscribe! http://bit.ly/ACSReactions Facebook! http://facebook.com/SpeakingOfChem Twitter! http://twitter.com/ACSReactions Tumblr! http://tumblr.com/ACSReactions Music is "Funk Soul Summer" by waggstar
Views: 8469 Reactions
Total Synthesis of Reserpine - R.B. Woodward
 
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Please consider supporting the channel on Patreon! https://www.patreon.com/SupremeScience Dr. Andrew Grant covers the Total Synthesis of Reserpine as described R.B. Woodward. Enjoy! Music by the wonderful Nathaniel Schroeder. https://soundcloud.com/drschroeder © ® The Nobel Foundation.
Views: 17230 Supreme Science
38. Review: Synthesis of Cortisone
 
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Freshman Organic Chemistry II (CHEM 125B) Discoverers of the structure and biological activity of steroid hormones won seven Nobel Prizes between 1927 and 1975. Studying the steps involved in Woodward's 1951 "total" synthesis of cortisone provides a review of the organic reactions covered this semester. Many steps involved novel insights, others were based on lore from previous work In the area. The overall yield of such sequential syntheses is typically much lower than that of convergent syntheses. Practical syntheses of cortisone were based on modification of related steroids readily available from nature. Milestones in total synthesis include both purely intellectual work with natural products and commercially important synthesis of designed pharmaceuticals. The course ends with thanks to those, young and old, who have taught us all. 00:00 - Chapter 1. Steroids and the Medicinal Activity of Cortisone 07:43 - Chapter 2. Woodward's Total Synthesis of Cortisone 33:27 - Chapter 3. Practical Synthesis of Cortisone 38:59 - Chapter 4. Some Milestones in Organic Synthesis 44:59 - Chapter 5. Thanks to Teachers, Colleagues, Family, and Students Complete course materials are available at the Open Yale Courses website: http://oyc.yale.edu This course was recorded in Spring 2011.
Views: 8864 YaleCourses
Total synthesis of solanoeclepin A; Rosa  Marie Noy
 
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Video Presentation of a scientific paper (AGRC1020) Animal Biology
Views: 151 Rosa- Marie Noy
R.B. Woodward Total Synthesis of Vitamin B12 Lecture - Part 2
 
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This is part 2 of a lecture that R.B. Woodward gave at Harvard University on November 27, 1972 following the completion of his total synthesis of vitamin B12 (in conjunction with Albert Eschenmoser). Here is part 1: https://youtu.be/YvEB05xdAy4
Views: 3331 Dylan Stiles
Nineteen-step total synthesis of phorbol
 
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Nineteen-step total synthesis of (+)-phorbol get Full Article http://bit.ly/1MHZ618 Phorbol, the flagship member of the tigliane diterpene family, has been known for over 80 years and has attracted attention from many chemists and biologists owing to its intriguing chemical structure and the medicinal potential of phorbol esters1. Access to useful quantities of phorbol and related analogues has relied on isolation from natural sources and semisynthesis.
Views: 115 Fik Izza
[Wikipedia] Total synthesis
 
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Total synthesis is the complete chemical synthesis of a complex molecule, often a natural product, from simple, commercially available precursors. It usually refers to a process not involving the aid of biological processes, which distinguishes it from semisynthesis. The target molecules can be natural products, medicinally important active ingredients, or organic compounds of theoretical interest. Often the aim is to discover new route of synthesis for a target molecule for which there already exist known routes. Sometimes no route exists and the chemist wishes to find a viable route for the first time. One important purpose of total synthesis is the discovery of new chemical reactions and new chemical reagents. https://en.wikipedia.org/wiki/Total_synthesis Please support this channl and help me upload more videos. Become one of my Patreons at https://www.patreon.com/user?u=3823907
Views: 1 WikiTubia
ShareBiotech | Paul Murphy, NUIG | The Chemistry Of Natural Products
 
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3 Sep 2012; Athlone Institute of Technology hosted presentations concerning new technologies in Natural Products. The meeting was focused on SME members of the Natural Products Biotechnology sector in Ireland a sought to clearly identify company perceptions of deficits regarding partnerships, collaborations, access to core facilities, required skills, training and effective networking within Ireland, the Atlantic Region of the EU and beyond.
Views: 1946 Sixsem
The Art of Chemical Synthesis
 
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The Center for Selective C-H Functionalization (CCHF) is leading a paradigm shift in the art of organic synthesis by bringing together experts from across a broad range of chemical disciplines. This collaborative network has an equally broad geographical distribution, with institutes from across the United States. http://nsf-cchf.com
Views: 14142 Emory University
7 Partial and Total Synthesis ch3 12th
 
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https://youtu.be/J38wIFmH26w https://youtu.be/J38wIFmH26w https://youtu.be/J38wIFmH26w
Dr. Yang, Total Synthesis Complex Natural Anti-cancer compound Taxol, Structure Modification lab.
 
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AZ Nature Art (www.aznpbio.com) ​9285 Dowdy Drive, Suite 103 San Diego, CA 92126 [email protected]; Tel: 360-464-3767 What We Can Do: Authentic identification of ethnomedicinal plants associated with common names, folk and historic uses, scientific definitions, description, likely alterations and synonyms Geographic distribution and abundance analysis Biological study and Efficacy review Raw material evaluation and sourcing (vendor audit and price investigation, available ingredient and extract purity, strength, composition, active compounds and content range) Comparison and selection of functional plants and ingredients for product formulation Safety evaluation including acute and chronic toxicities, LD50, effects on infants and reproductive organs Irritation and allergy assesment Dosage range suggestion Novelty assessment and patent claims construction Assessment and prediction of oral availability and tissue distribution Quality control method design (UV, HPLC, TLC, HPTLC, GC or GC/MS, organic solvent residues, microbial, heavy metals, and pesticides in standardized extract, compound and ingredient) Manufacturing methods We also supply herbs, raw materials, authentic extracts and cutting-edge science-based functional ingredients. AZNPbio is a San Diego, California (CA) based, privately-held bio-tech company engaged in natural product sourcing, collection, extraction, purification and manufacturing to serve health product company’s ever-growing new target and ingredient developments. We have operations and collaborations in US and China. Our library includes more than 8000 bio-collections from over 3500 genera. Currently 5000 extracts purified from 3000 plant species, and 7000 HPLC-isolated compounds and fractions are ready for bio-active screening. One-third of our collections have origin from the Middle East and Africa. With samples derived from lichen, liverwort, fern, algae, mushroom, aquatics, marine, worm, higher plants and insects for bio-screening (HTS), generating hit-to-lead and preclinical candidates; AZNPbio can help grow your R&D pipeline of new drugs, cosmetics, preservatives, natural flavors, herbcides and pesticides.
Views: 144 Jeff Zhao
The First Steroid Synthesis: History, Bachmann's Equilenin, Retrosynthetic Strategies
 
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In this video we will talk about the total synthesis of steroid hormones in the early 20th century. After an introduction into the history of steroids and challenges with steroid and natural product isolation, we will go through the retrosynthetic analysis Welcome to this channel around the topic of organic synthesis. This is not an experimental channel showcasing chemical experiments but rather will deal with theoretical discussions of syntheses of important chemicals and interesting natural products. If you are not familiar with organic chemistry, do not expect to understand everything I'm talking about. Please consult the literature, the myriad of youtube videos about basic chemistry or just Google. Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of reactions and applications thereof with common conditions) - Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
Views: 373 Total Synthesis
Natural Product Discovery
 
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Associate Professor Thomas Ostenfeld Larsen, who heads the research group Natural Product Discovery at DTU Systems Biology talks about the group’s discovery and engineering of novel natural products from an array of organisms. Products that may be used to solve some of the challenges society face today. One example is a very large project where they sequence all known species in genus aspergillus. This will give them first hand access to genomics driven discovery of silent gene clusters and engineering of these to produce the potentially new drug lead candidate of the future.
Views: 511 Mette Haagen
Partial and Total Synthesis
 
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Chemistry_c-9-10-org-chem-68.mp4
Views: 2200 Sabaq. Pk
Chemistry Is All About Perspective - Twistane Total Synthesis
 
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Please consider supporting the channel on Patreon! https://www.patreon.com/SupremeScience In this video, Dr. Andrew Grant explores how looking at target molecules in different light, give new insight into Organic Synthetic Strategies. He achieves this by tackling the total synthesis and history of a unique molecule, Twistane. Enjoy! Music by the wonderful Nathaniel Schroeder. https://soundcloud.com/drschroeder
Views: 3701 Supreme Science
Synthesis of Drugs
 
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Short podcast describing how new drugs are synthesized
Views: 21327 Bob Gotwals
Synthesis of Lysergic Acid: History, Strategies and Reaction Mechanisms
 
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Please excuse some slight audio pops; I'll keep in mind to keep the mic further away next time. Welcome to this channel around the topic of organic synthesis. This is not an experimental channel showcasing chemical experiments but rather will deal with theoretical discussions of syntheses of important chemicals and interesting natural products. If you are not familiar with organic chemistry, do not expect to understand everything I'm talking about. Please consult the literature, the myriad of youtube videos about basic chemistry or just Google. In this first video, we will cover the history of lysergic acid, a LSD precursor, its first total synthesis and a modern approach (with increasing difficulty). I threw in some sidenotes and anecdotes to make the material slightly less dry. 00:00 Introduction about the significance of lysergic acid derivatives and importance of natural products 00:49 Overview 02:09 History preceding the synthesis of lysergic acid about the work of Albert Hofmann at Sandoz (first semisynthesis) 04:12 First total synthesis by chemists at Lilly & Nobel laureate Robert Burns Woodward. This synthesis employs reactions encountered at in the first two years at an undergrad level. 12:40 Modern approach by Prof. Ohno at Kyoto University. This contemporary synthesis relies on organometallic chemistry and more advanced retrosynthetic disconnections. This part contains a short discussion of reaction mechanism. 18:10 Closing comments Tell me whether I should continue doing such videos and if so, whether I should focus on "easy" approaches or more advanced ones (or make two types of videos and do both of them). Subscribe and like this video if you want to show your support. Albert Hofmann's notes: http://www.psychedelic-library.org/hofmann.htm Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of reactions and applications thereof with common conditions) - Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
Views: 3702 Total Synthesis
Total Synthesis of Ginkgolide B
 
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Update!! Finally, I have made a video of Ginkgolide B with commentary. You can check out part 1 here: https://youtu.be/V76kv4hO3WQ and part two here: https://youtu.be/Ish0ld3Oi0o Part one of the Total Synthesis of Ginkgolide B Music by Kevin MacLeod (The Descent)
Views: 2005 OrganicChemistOnCall
Total Synthesis of Longifolene
 
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In this video you will find a brief overview of the total synthesis of longifolene. Each reaction is discussed in detail. Youtube Channel (Hindi) - https://www.youtube.com/channel/UCmIchtf7_PvcAOfT5p5f6eQ Unacademy - https://unacademy.com/user/Sethi Disclaimer The information provided on this channel is a public service with the understanding that Gate Chemistry makes no warranties, either expressed or implied, related to completeness, accuracy, reliability or suitability of the information. The channel disclaims liability for errors and omissions that may have crept in its content.
Views: 965 Gate chemistry
100 Years of Natural Product Synthesis Mobile
 
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History of Organic Chemistry at the Helsinki University of Technology Chemistry Deparment starting form Komppa to 2003
Views: 346 Ari Koskinen
Carl Djerassi - Working on natural products of chemistry (82/117)
 
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Austrian-American Carl Djerassi (1923-2015) was born in Vienna. He revolutionised the field of female contraception when he and his team of chemists produced synthetic progesterone which led to the development of the first oral contraceptive pill. [Listener: Tamara Tracz] TRANSCRIPT: In Mexico I was entirely a synthetic chemist, I was making things with an object to make them, so that they can be used for medicinal purposes, mostly by synthetic chemists, but the cacti, it really started with that. I just developed a curiosity of what’s in it, and that led me to start working on cactus chemistry, and very few people worked on cactus chemistry, there was really only one natural product that was famous, if not notorious, and that was mescaline from peyote buttons, but these were small cacti. They were from Mexico, but they were small, and not the really giant treelike ones here, and so I focused on that and we did- I probably did, maybe a dozen PhD thesis’s, and many post docs who worked on the constituents of giant cacti, and we did some very important work. And it had no- there were no practical consequences of this, and I didn’t even mean there to be, but chemically they were extremely interesting, and that led me also to alkaloid work, and to- what I really found were interesting, triterpines, and triterpines are compounds that look like, like steroids, but are even more complex. I don’t know whether I have some- I may have some structures in here? No, probably not. Chemical structures, but I worked on these, and that led me to alkaloid chemistry, and that led me to antibiotic chemistry, but it led me to the structure elucidation of compounds, rather than to the synthesis of it. And structurally I’ll use, not quite an architectural metaphor, which you try to use for synthesis, to try and draw the difference between total synthesis and partial synthesis, but a different one, and at that time it was, I think for me, intellectually an even more challenging one, and it was something which was primarily practised in Europe, and later also in Japan, and much less so in the United States, which sort of, continued my sort of outside status I mentioned, even in, in chemical priorities. Namely, natural products of chemistry means to identify the chemical structure of chemicals in natural products, and that was the first priority, and the next one was what could you use them for, or why are they there, and then finally, even how are they synthesised by that plant or animal? Most of them were plants at that time. The analogy is that you walk into a pitch dark room, a furnished room, and you want to find out what is in this room, and by that I mean what sort of furniture, and initially, just are there tables, beds, chairs, what are they made out of, what are their shapes, what are their colours, and so on and so forth? And in the end, how are they made, why are they made, why is that there, assuming that you don’t even know what a chair is, and a table? Now, how would you do that if you go in a pitch-dark room and you have nothing? All you can do is grope around and you feel with your fingers, and sometimes you can be grossly misled, and sometimes you wouldn’t be. This is a good example, this table here, which is oval. Well, you know, when you feel it around you would not necessarily think that this is actually a table, and even the material is an unusual material for a table. This happens to be metal, and most dining room tables are not really metal like this, and it wouldn’t feel that way, so you could already be misled if you just did it by feeling, although eventually you might be able to figure it out. Well, the next thing you do is you try and at least light a match, and when you light a match you can really illuminate only very little, and for only a very short period of time, so you have to either light a lot of matches and do it gradually, and then discover it, or maybe if you are lucky you can try and get a candle, and then you can see more, and maybe a flashlight, and so on. Now, of course the ideal thing would be if you would take a photograph, and in fact, if you take a colour photograph then you’ve got everything there. With one photograph with a wide angle lens you take the entire room, you see it right there, and you even see it in colour, and then you can already extrapolate very much what the materials are there, although not necessarily entirely, so that’s exactly what natural product chemistry is. You want to know what is in that particular plant, let us say, but.... Visit [https://www.webofstories.com/play/carl.djerassi/82] to read the remaining part of the transcript and to view more of Carl Djerassi's inspiring thoughts and life stories.
Search for and synthesis of natural organic compounds with unique structures and functions
 
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The Nakata-Saikawa Research Lab in the Department of Applied Chemistry at Keio University’s Faculty of Science and Technology conducts research on organic chemistry of natural products. Q. The natural world has many mysterious phenomena and ingenious tricks that we would never think of. By synthesizing challengingly complex structured organic compounds, or by explaining the nature of yet to be understood mysterious organic phenomena at the molecular level, we think we can discover new compounds, new properties of compounds, and new organic chemical reactions. The Nakata-Saikawa Research Lab has been conducting synthesis research targeting natural organic compounds with complex and unique structures. As part of this research, during the synthesis of the ansa compound kendomycin, under a new method using the Dotz reaction to form an aromatic core while simultaneously generating a ring, the lab has successfully synthesized abundantly varied ansa compounds that cannot be created in the natural world. Q. Ansa compounds have interesting structures so they are fun to make, and quite a variety of bioactive compounds are produced, so in fact some are used in medicines. Of these, kendomycin is a compound that relatively recently was isolated and had its structure determined. From that time it was being targeted by synthetic chemists. We too have focused on synthesizing kendomycin, which may become a lead compound of pharmaceutical drugs, in an interesting manner. In addition to the synthesis of compounds, the Nakata-Saikawa Research Lab is focused on physiological phenomena and natural phenomena in organisms, conducting research to extract related organic compounds. Among this is research on a chemical substance that causes sneezing. Q. There is a red striped jellyfish called chrysaora pacifica. When it gets caught in a fishing net and turns into a powder after becoming dried out and stale, it has long been said that people will sneeze uncontrollably just by passing by it. What is it that causes the sneezing? It is something that causes everybody to sneeze, so to figure out what it is, we caught some chrysaora pacifica and made it into a powder. Using mice, we are administering a sample in their noses and counting the number of sneezes as a method to discover the inducing substance. At this point it appears that the substance is very unstable. It is not as if we understand its structure yet, but we have started to see that the substance causing the sneezing is something unique, so we think this research has become interesting. In addition, the Nakata-Saikawa Research Lab is also conducting fascinating research to explain the mechanisms of biological phenomena. This includes extracting compounds involved in the phenomenon of the calcium in an egg shell moving to the bones of a chick when the chick grows inside the egg. Q. When you look around there are many interesting natural phenomena. Look at the various things around you and give it some thought as to how in the world they became like that. When you do this, you will discover that there are still many extremely interesting unexplained phenomena. If we continue to work hard researching to explain them, I think we will definitely discover some interesting science, so I want everyone to join the world of science.
Total synthesis of Azumamides and analogs
 
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Jesper Villadsen presents his PhD project
Views: 738 DTUdk
Natural Products
 
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Chemical and Spectral approach to Natural Products In early time, element detection , percent composition and determining its empirical formula Modern technique: Includes six inquiries: Physical properties Classification by solubility Classification tests by functional groups Chromatographic analysis Spectroscopic analysis Synthesis of solid derivatives
Views: 67 Parjanya Shukla
Natural Products
 
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Natural Products . . . . . . Natural products are the chemical compounds found in nature that usually has a pharmacological or biological activity for use in pharmaceutical drug discovery and drug design. Natural Products Journals | Peer Reviewed | High Impact ... esciencecentral.org/journals/natural-products-chemistry-research.php More about Natural product Feedback Natural product - Wikipedia, the free encyclopedia en.wikipedia.org/wiki/Natural_product Natural products can also be prepared by chemical synthesis (both semisynthesis and total synthesis) and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets. ‎Classes - ‎Function - ‎Biosynthesis - ‎Sources Journal of Natural Products (ACS Publications and Am. Soc ... pubs.acs.org/journal/jnprdf Alla A. Kicha, Anatoly I. Kalinovsky, Timofey V. Malyarenko, Natalia V. Ivanchina, Pavel S. Dmitrenok, Ekaterina S. Menchinskaya, Ekaterina A. Yurchenko, ... ‎List of Issues - ‎Articles ASAP - ‎Manuscript Submission and ... - ‎Current Issue Natural Product Chemistry www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/biomol.htm Natural Products. Organic chemistry had its genesis in the study of naturally occurring substances, and this remains a constant source of information and ... Images for Natural ProductsReport images Image result for Natural Products Image result for Natural Products Image result for Natural Products Image result for Natural Products More images for Natural Products Natural Products Association www.npainfo.org/ Tell the FDA to Protect Access to Homeopathic Products ... New York Attorney General and Natural Products Association Agree to Collaborate to Promote ... Natural Products Journals | Peer Reviewed | High Impact ... esciencecentral.org/journals/natural-products-chemistry-research.php Natural products are the chemical compounds found in nature that usually has a pharmacological or biological activity for use in pharmaceutical drug discovery and drug design. Natural Product Reports pubs.rsc.org › Journals High impact, critical reviews in natural products research and related areas. Natural Product Updates pubs.rsc.org › Databases by WJ Chung - ‎2013 - ‎Cited by 11 - ‎Related articles Natural Product Updates is a literature updating service keeping you current with recent developments in natural products chemistry. Relevant content is ... Studies in Natural Products Chemistry - ScienceDirect.com www.sciencedirect.com/science/bookseries/15725995 The online version of Studies in Natural Products Chemistry at ScienceDirect.com, the world's leading platform for high quality peer-reviewed full-text journals. Dictionary of Natural Products dnp.chemnetbase.com/intro/ The Dictionary of Natural Products (DNP) is the only comprehensive and fully-edited database on natural products. It arose as a daughter product of the ...
Total Synthesis of AMF-26 (M-COPA), an Antitumor Agent for Inhibition of the Golgi System
 
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Tokyo University of Science and Japanese Foundation for Cancer Research Feb. 7, 2013, Press Conference Shiina I. et al., Journal of Medicinal Chemistry, 56, 150-159 (2013).
Views: 14267 dkrnsaids
Synthesis of Colouring Agent (Natural Products)
 
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This video, was once distributed for community service schemes in Gowa Regency South Sulawesi (Sept 9, 2015), is now dedicated for undergraduate students of Pharmacy UNHAS to uplift their out-of-textbook-knowledge.
Views: 271 Yusnita Rifai
Zhendong Jin Associate Professor PhD
 
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Dr. Jin researches the total synthesis of biologically active natural products & structural analogues, development of new synthetic methods with interest in asymmetric reactions, & synthesis of small libraries with the aim of anticancer drug discovery.
Views: 490 MNPCUI
What is BIOMIMETIC SYNTHESIS? What does BIOMIMETIC SYNTHESIS mean?
 
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What is BIOMIMETIC SYNTHESIS? What does BIOMIMETIC SYNTHESIS mean? BIOMIMETIC SYNTHESIS meaning - BIOMIMETIC SYNTHESIS definition - BIOMIMETIC SYNTHESIS explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/by-sa/3.0/ license. Biomimetic synthesis is an area of organic chemical synthesis that is specifically biologically inspired, so-named in 1917 by the English organic chemist and Nobel laureate Sir Robert Robinson. The term encompasses both the testing of a "biogenetic hypothesis" (conjectured course of a biosynthesis in nature) through execution of a series of reactions designed to parallel the proposed biosynthesis, as well as programs of study where a synthetic reaction or reactions aimed at a desired synthetic goal are designed to mimic a one or more known enzymic transformations of an established biosynthetic pathway. The earliest generally cited example of a biomimetic synthesis is Robinson's organic synthesis of the alkaloid tropinone. A more recent example is E.J. Corey's carbenium-mediated cyclization of an engineered linear polyene to provide a tetracyclic steroid ring system, which built upon studies of cationic cyclizations of linear polyenes by the Albert Eschenmoser and Gilbert Stork, and the extensive studies of the W.S. Johnson to define the requirements to initiate and terminate the cyclization, and to stabilize the cationic carbenium group during the cyclization (as nature accomplishes via enzymes during biosynthesis of steroids such as cholesterol). In relation to the second definition, synthetic organic or inorganic catalysts applied to accomplish a chemical transformation accomplished in nature by a biocatalyst (e.g., a purely proteinaceous catalyst, a metal or other cofactor bound to an enzyme, or a ribozyme) can be said to be accomplishing a biomimetic synthesis, where design and characterization of such catalytic systems has been termed biomimetic chemistry. Proto-Daphniphylline is a precursor in the biosynthesis of a family of alkaloids found in Daphniphyllum macropodum. It is of interest due to its complex molecular structure making it a challenging target for conventional organic synthesis methods due to the fused ring structure and the spiro carbon centre. Based on a proposed biosynthesis pathway of proto-daphniphylline from squalene, Clayton Heathcock and co-workers developed a remarkably elegant and short total synthesis of proto-Daphniphylline from simple starting materials. This is a classic example of how biomimetic synthesis dramatically simplifies traditional total synthesis towards complex natural products. The key step in Heathcock’s synthetic route involves a cyclization of acyclic dialdehydes A or B to form proto-daphniphylline. Both dialdehydes (A or B) have carbon skeletons analogous to squalene and can be synthesized from simple starting materials. Treating A or B with a sequence of simple reagents containing potassium hydroxide, ammonia, and acetic acid led to the formation of proto-daphniphylline. Six ?-bonds and five rings were formed in this remarkable step. It was proposed in the original report that hydroxyldihydropyran intermediate C was first formed when the dialdehyde starting material (A) was treated with potassium hydroxide. A 2-aza-1, 3-diene intermediate (D) was generated from the reaction of intermediate C with ammonia. An acid-catalyzed Diels-Alder reaction formed intermediate E which was further converted to the final product under the reaction conditions.
Views: 510 The Audiopedia
6 Plants and Natural Products Chemistry ch3 12th
 
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https://youtu.be/C0HYJtRVBpA https://youtu.be/C0HYJtRVBpA https://youtu.be/C0HYJtRVBpA
Biosynthesis of polyketide natural products
 
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Biosynthesis of polyketide natural products; Chapters: 0:00 - Introduction; 00:45 - Aims and objectives; 04:45 - Biosynthesis of natural products; 08:00 - Biosynthesis of natural products; 10:00 - Making the polyketide chain; 15:45 - Coenzyme A; 29:30 - The missing link; 32:15 - Folding of the poly-beta-ketoester (C-C bond); 40:15 - Claisen or aldol;
Views: 13234 DTUdk
Fisching for Marks
 
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This extremely serious documentary outlines how the Fischer Indole Synthesis works, the uses of indoles and of course, high quality interviews that is guaranteed to get full marks for our Advanced Organic Chemistry group assignment. Special thanks to Andrew Wrangell for his kind permission to use his original song Be Bold. Check out his YouTube channel Andrew Wrangell Music! https://www.youtube.com/watch?v=lEHgxgzGqdE (P.S. Andrew also runs the YouTube channel Sheet Music Boss if you also wanted to chek it out: https://www.youtube.com/channel/UCzTR9iSH-TFC4-ocDS_ll4A) Also, The Kooks' song "Be Who You Are" was playing in the background for an interview. Unfortunately we had no control over this sooo... Thanks guys for letting us use your music??? References: Heravi, M.M., Rohani,  S., Zadsirjan, V., Zahedi, N. (2017). Fischer indole synthesis applied to the total synthesis of natural products. The Royal Society of Chemistry, 7, 52852-52887. doi: https://doi.org/10.1039/C7RA10716A. McIntosh, J. (2018). What is serotonin and what does it do? Retrieved from https://www.medicalnewstoday.com/kc/serotonin-facts-232248. Name Reaction. (2018). Fischer Indole Synthesis. Retrieved from https://www.name-reaction.com. Nobel Media AB. (2014). The Nobel Prize in Chemistry 1902. Retrieved from www.nobelprize.org. Pub Chem. (n.d.). Indole. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/indole#section=Top. RxList. (2018). Indole-3-carbinol. Retrieved from https://www.rxlist.com/indole-3-carbinol/supplements.htm. Science Direct. (2018). Indole. Retrieved from https://www.sciencedirect.com/topics/neuroscience/indole. Sung, W.S., Lee, D.G. (2007). The Candidacical Activity of Indole-3-Carbinol that Binds with DNA. IUBMB Life, 59(6), 408-412. Web MD. (2017). What is Melatonin? Retrieved from https://www.webmd.com/sleep-disorders/what-is-melatonin.
Views: 120 Meredith Navin
What IS Organic Synthesis?
 
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Please consider supporting the channel on Patreon! https://www.patreon.com/SupremeScience What is Organic Synthesis, and what is involved? - As Fast as Possible. Enjoy! Music by the wonderful Nathaniel Schroeder. https://soundcloud.com/drschroeder
Views: 8983 Supreme Science
Total Synthesis of Belizentrin Methyl Ester
 
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work by Alois Fürstner and colleagues, Max Planck Institute for Coal Research, Mülheim, Germany, published in Angewandte Chemie https://www.chemistryviews.org/details/ezine/11082120/Total_Synthesis_of_Belizentrin_Methyl_Ester.html
DYES, TYPES OF DYES AND DYES USES
 
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Download SCIENCETUTS App to Access 120+ hours of Free content. For more information: http://www.7activestudio.com [email protected] http://www.7activemedical.com/ [email protected] http://www.sciencetuts.com/ Contact: +91- 9700061777, 040-64501777 / 65864777 7 Active Technology Solutions Pvt.Ltd. is an educational 3D digital content provider for K-12. We also customise the content as per your requirement for companies platform providers colleges etc . 7 Active driving force "The Joy of Happy Learning" -- is what makes difference from other digital content providers. We consider Student needs, Lecturer needs and College needs in designing the 3D & 2D Animated Video Lectures. We are carrying a huge 3D Digital Library ready to use. An acid dye is a dye which is a salt of a sulfuric, carboxylic or phenolic organic acid. The salts are often sodium or ammonium salts. Acid dyes are typically soluble in water and possesses affinity for amphoteric fibers while lacking direct dyes' affinity for cellulose fibers. These dyes are made from synthetic resources such as petroleum by-products and earth minerals. The first human-made organic aniline dye, mauveine, was discovered serendipitously by William Henry Perkin in 1856, the result of a failed attempt at the total synthesis of quinine. Soda Ash Dye Fixer. Soda ash is a mild alkali that promotes the chemical reaction between Procion MX fiber reactive dye and cellulose fiber. Soda ash is also known as sodium carbonate, washing soda, or sal soda.
Views: 23787 7activestudio
Science Book Review: Classics in Total Synthesis: Targets, Strategies, Methods by K. C. Nicolaou,...
 
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http://www.ScienceBookMix.com This is the summary of Classics in Total Synthesis: Targets, Strategies, Methods by K. C. Nicolaou, E. J. Sorensen.
Views: 333 ScienceBookMix
"Total Synthesis of a Functional Designer Eukaryotic Chromosome" - C5 Group 48
 
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This is a video made by Mathew Samuel, Lily Ngyuen, Robert Memmer, and Stephanie Hoang for BIO 1510 at the Georgia Institute of Technology. This is an educational video based on the research article on the "Total Synthesis of a Functional Designer Eukaryotic Chromosome".
Views: 184 Mathew Samuel